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KMID : 1123920070210030728
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.728 ~ p.735
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Study on the Effect of Gwanjulbang-5 in Rheumatoid Arthritis
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Choi Jae-Young
Heo Dong-Seok
Yoon Il-Ji
Oh Min-Seok
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Abstract
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This study was carried out to know the effect of Gwanjulbang-5(hereinafter refer to GJB-5) to on Rheumatoid Arthritis by using human fibroblast-like synoviocytes(hFLS). We performed several experimetal items : that is cytotoxicity of GJB-5, mRNA expression of pro-imflammatory cytokines in hFLS and production of NO, ROS. The results were obtained as follows : GJB-5 reduced the production of pro-inflammatory cytokines TNF-, IL-1, IL-6, IL-8 in hFLS, increased the production of TIMP-1. As well as GJB-5 reduced the production of ICAM-1, MMP-3, NOS-II, the production of NO and ROS, and the proliferation of hFLS in proportion to the concentration of GJB-5. In conclusion, these results shows that GJB-5 had immunomodulatory effects in treating rheumatoid arthritis.
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KEYWORD
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Gwanjulbang-5, Rheumatoid Arthritis, immunomodulatory, Pro-inflammatory cytokines, Human fibroblast-like synoviocytes(hFLS)
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